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Index > Protein center > Kiss1(Gene name) > Mouse
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  • Kiss1 (Gene name),
  • Metastasis-suppressor KiSS-1 (Protein name ),  KISS1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Kiss1;
    Protein name:
    Metastasis-suppressor KiSS-1;
    Alternative:
    Kisspeptin-1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Intracerebroventricular administration induces an increase in serum LH and FSH levels in prepubertal male and female as well as in adult animals.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    130
    Sequence:
    50:
    MISMASWQLL | LLLCVATYGE | PLAKVAPLVK | PGSTGQQSGP | QELVNAWEKE | 
    100:
    SRYAESKPGS | AGLRARRSSP | CPPVEGPAGR | QRPLCASRSR | LIPAPRGAVL | 
    130:
    VQREKDLSTY | NWNSFGLRYG | RRQAARAARG | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Metastasis-suppressor KiSS-1
    Cat.:
    E2063r
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Metastasis-suppressor KiSS-1
    Cat.:
    E2063h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Metastasis-suppressor KiSS-1
    Cat.:
    E2063m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Metastasis-suppressor KiSS-1
    Cat.:
    U2063r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Metastasis-suppressor KiSS-1
    Cat.:
    U2063h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Metastasis-suppressor KiSS-1
    Cat.:
    U2063m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Metastasis-suppressor KiSS-1
    Cat.:
    P2063Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Metastasis-suppressor KiSS-1
    Cat.:
    P2063Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Metastasis-suppressor KiSS-1
    Cat.:
    P2063Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Metastasis-suppressor KiSS-1
    Monoclonal Antibody for Mouse Metastasis-suppressor KiSS-1
    Monoclonal Antibody for Mouse Metastasis-suppressor KiSS-1
    Protein for Mouse Metastasis-suppressor KiSS-1
    Protein for Mouse Metastasis-suppressor KiSS-1
    Protein for Mouse Metastasis-suppressor KiSS-1

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    Linearity
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    References
    1. 1.
      "Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor."
      Stafford L.J. , Xia C. , Ma W. , Cai Y. , Liu M.
      Cancer Res.62:5399-5404(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION;TISSUE SPECIFICITY
      strain: 129S6/SvEvTac.
      tissue: Brain.
    2. 2.
      "Expression of KiSS-1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta."
      Terao Y. , Kumano S. , Takatsu Y. , Hattori M. , Nishimura A. , Ohtaki T. , Shintani Y.
      Biochim. Biophys. Acta1678:102-110(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Embryo.
    3. 3.
      "Identification and characterization of metastin in the mouse spinal cord."
      Ohsawa M. , Chi M. , Ohtsubo Y. , Brailoiu G.C. , Yang J. , Chang J. , Dun N.J.
      Submitted (2004-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: ICR.
      tissue: Brain.
    4. 4.
      "The genesis of the human KISS1."
      Xie H. , Bonaldo M.F. , Soares M.B.
      Submitted (2004-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Placenta.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    6. 6.
      "A role for kisspeptins in the regulation of gonadotropin secretion in the mouse."
      Gottsch M.L. , Cunningham M.J. , Smith J.T. , Popa S.M. , Acohido B.V. , Crowley W.F. , Seminara S. , Clifton D.K. , Steiner R.A.
      Endocrinology145:4073-4077(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;ROLE IN THE REGULATION OF GONADOTROPIN SECRETION
    7. 7.
      "Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat."
      Irwig M.S. , Fraley G.S. , Smith J.T. , Acohido B.V. , Popa S.M. , Cunningham M.J. , Gottsch M.L. , Clifton D.K. , Steiner R.A.
      Neuroendocrinology80:264-272(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN REGULATION OF GONADOTROPIN SECRETION
    8. 8.
      "Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54."
      Navarro V.M. , Fernandez-Fernandez R. , Castellano J.M. , Roa J. , Mayen A. , Barreiro M.L. , Gaytan F. , Aguilar E. , Pinilla L. , Dieguez C. , Tena-Sempere M.
      J. Physiol. (Lond.)561:379-386(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54."
      Navarro V.M. , Castellano J.M. , Fernandez-Fernandez R. , Tovar S. , Roa J. , Mayen A. , Nogueiras R. , Vazquez M.J. , Barreiro M.L. , Magni P. , Aguilar E. , Dieguez C. , Pinilla L. , Tena-Sempere M.
      Endocrinology146:156-163(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN LUTEINIZING HORMONE SECRETION
    10. 10.
      "Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54."
      Messager S. , Chatzidaki E.E. , Ma D. , Hendrick A.G. , Zahn D. , Dixon J. , Thresher R.R. , Malinge I. , Lomet D. , Carlton M.B. , Colledge W.H. , Caraty A. , Aparicio S.A.J.R.
      Proc. Natl. Acad. Sci. U.S.A.102:1761-1766(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DIRECT STIMULATION OF GONADOTROPIN-RELEASING HORMONE RELEASE
    11. 11.
      "Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat."
      Navarro V.M. , Castellano J.M. , Fernandez-Fernandez R. , Tovar S. , Roa J. , Mayen A. , Barreiro M.L. , Casanueva F.F. , Aguilar E. , Dieguez C. , Pinilla L. , Tena-Sempere M.
      Endocrinology146:1689-1697(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN FOLLICLE-STIMULATING HORMONE SECRETION
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
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